Mental disorders, post-traumatic stress disorders, cognitive disorders, neurological disorders, autism spectrum disorders and deafblindness. At first glance, the areas of intervention of the endowment fund may seem to pose challenges without a common field of action. In fact, they are completely different disabilities, following an accident or an illness, but they are similar in that the people who suffer from them are those left behind, the stigmatized and, often even, the invisible or rather those we don't want to see, from our society. Since the end of the 20th century, the question of integration and social participation of people living with disabilities has been one of the priority objectives of public policies. These objectives are repeatedly confronted, for the audiences targeted by our fields of action, with obstacles of the following nature: -organizational (lack of resources allocated by public authorities); -professional (lack of training); -socio-affective (prioritization of objectives based on the appreciation of different types of disability, stigma, discrimination); -cultural (norms and social reference values). Questioning these “brakes” constitutes an important challenge for the prefiguration endowment fund of the Jean-Jacques Puyoo foundation. Fight against negative social representations, work for better educational and medico-social care with a view to better integration, give caregivers the tools to access good support, organize discussion and mutual aid groups to fight against isolation, thinking of innovative and intergenerational projects putting people at the heart of priorities and finally training nursing staff but also patients themselves to further fight against stigma and encourage self-esteem: these are all actions proposed to provide an element of response to these “brakes” and remove them to truly press the accelerator in order to move towards a more inclusive and united world.